Prediction of immunotherapy efficacy and immunomodulatory role of hypoxia in colorectal cancer

Z Zheng, C Bian, H Wang, J Su… - Therapeutic …, 2022 - journals.sagepub.com
Immunotherapy has been used in the clinical treatment of colorectal cancer (CRC); however,
most patients fail to achieve satisfactory survival benefits. Biomarkers with high specificity …

[HTML][HTML] Roxadustat: Do we know all the answers?

QY Li, QW Xiong, X Yao, F Liu, X Tang… - Biomolecules and …, 2023 - ncbi.nlm.nih.gov
Anemia is a common complication of chronic kidney disease (CKD), and its prevalence rises
as the disease progresses. Intravenous or subcutaneous erythropoiesis-stimulating agents …

Gasdermin D in macrophages drives orchitis by regulating inflammation and antigen presentation processes

C Ma, J Huang, Y Jiang, L Liu, N Wang… - EMBO Molecular …, 2024 - embopress.org
Inflammation in the testes induced by infection and autoimmunity contributes significantly to
male infertility, a public health issue. Current therapies using antibiotics and broad-spectrum …

Reoxygenation modulates the adverse effects of hypoxia on wound repair

Q Bai, Q Gao, F Hu, C Zheng, N Sun, W Chen… - International journal of …, 2022 - mdpi.com
Hypoxia is a major stressor and a prominent feature of pathological conditions, such as
bacterial infections, inflammation, wounds, and cardiovascular defects. In this study, we …

Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis

PP Cunha, D Bargiela, E Minogue, LCM Krause… - Cancer immunology …, 2023 - AACR
Nitric oxide (NO) is a signaling molecule produced by NO synthases (NOS1–3) to control
processes such as neurotransmission, vascular permeability, and immune function …

Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review

H Ruan, Q Zhang, Y Zhang, S Li, X Ran - Critical Care, 2024 - Springer
Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory
response triggered by infection, involving multifactorial and intricate molecular mechanisms …

[HTML][HTML] The IFN-γ receptor promotes immune dysregulation and disease in STING gain-of-function mice

WA Stinson, CA Miner, FR Zhao, AJ Lundgren… - JCI insight, 2022 - ncbi.nlm.nih.gov
STING gain-of-function mutations cause STING-associated vasculopathy with onset in
infancy (SAVI) in humans, a disease characterized by spontaneous lung inflammation and …

Recent Advances and Therapeutic Implications of 2-Oxoglutarate-Dependent Dioxygenases in Ischemic Stroke

J Xie, Z Zhang - Molecular Neurobiology, 2024 - Springer
Ischemic stroke is a common disease with a high disability rate and mortality, which brings
heavy pressure on families and medical insurance. Nowadays, the golden treatments for …

Network analysis to explore the pharmacological mechanism of Shenmai injection in treating granulocytopenia and evidence-based medicine approach validation

X Hou, D Chen, Y Wang, B Cui, H Xu, Y Wang, H Chen… - Medicine, 2023 - journals.lww.com
Background: Shenmai injection is frequently utilized in China to clinically treat
granulocytopenia in oncology patients following chemotherapy. Despite this, the drug's …

Effect of dexmedetomidine up-regulating HIF-1ɑ on intestinal mucosal barrier injury related to sepsis in rats

X Lei, B Zhao, J Li, S Huang, Y Li, S Zhu - 2022 - researchsquare.com
Dexmedetomidine (DEX), a highly selective α 2 receptor agonist. DEX can inhibit the
release of inflammatory factors in septic rats. It can also protect against H 2 O 2 injury by up …