Assessing spatial learning and memory in rodents

CV Vorhees, MT Williams - ILAR journal, 2014 - academic.oup.com
Maneuvering safely through the environment is central to survival of almost all species. The
ability to do this depends on learning and remembering locations. This capacity is encoded …

Applications of the Morris water maze in translational traumatic brain injury research

LB Tucker, AG Velosky, JT McCabe - Neuroscience & Biobehavioral …, 2018 - Elsevier
Acquired traumatic brain injury (TBI) is frequently accompanied by persistent cognitive
symptoms, including executive function disruptions and memory deficits. The Morris Water …

Functional aging in male C57BL/6J mice across the life-span: a systematic behavioral analysis of motor, emotional, and memory function to define an aging phenotype

S Yanai, S Endo - Frontiers in aging neuroscience, 2021 - frontiersin.org
Aging is characterized generally by progressive and overall physiological decline of
functions and is observed in all animals. A long line of evidence has established the …

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

N Maphis, G Xu, ON Kokiko-Cochran, S Jiang… - Brain, 2015 - academic.oup.com
Pathological aggregation of tau is a hallmark of Alzheimer's disease and related
tauopathies. We have previously shown that the deficiency of the microglial fractalkine …

Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats

C Boitard, A Cavaroc, J Sauvant, A Aubert… - Brain, behavior, and …, 2014 - Elsevier
In addition to metabolic and cardiovascular disorders, obesity pandemic is associated with
chronic low-grade inflammation as well as adverse cognitive outcomes. However, the …

Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain

W Deng, MD Saxe, IS Gallina… - Journal of Neuroscience, 2009 - Soc Neuroscience
Adult-born dentate granule cells (DGCs) contribute to learning and memory, yet it remains
unknown when adult-born DGCs become involved in the cognitive processes. During …

Explicit memory creation during sleep demonstrates a causal role of place cells in navigation

G De Lavilléon, MM Lacroix, L Rondi-Reig… - Nature …, 2015 - nature.com
Hippocampal place cells assemblies are believed to support the cognitive map, and their
reactivations during sleep are thought to be involved in spatial memory consolidation. By …

Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats

B Ghadrdoost, AA Vafaei, A Rashidy-Pour… - European journal of …, 2011 - Elsevier
Although it is well established that chronic stress impairs spatial learning and memory, few
studies have investigated possible ways to prevent its deleterious effects. Here, we …

Spatial memory: Theoretical basis and comparative review on experimental methods in rodents

CM Paul, G Magda, S Abel - Behavioural brain research, 2009 - Elsevier
The assessment of learning and memory in animal models has been widely employed in
scientific research for a long time. Among these models, those representing diseases with …

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting

A Awasthi, B Ramachandran, S Ahmed, E Benito… - Science, 2019 - science.org
INTRODUCTION Memories are stored as molecular and cellular changes in the brain.
Synapses, the nodes of connection between neurons, can store memories by virtue of their …