WWOX and its binding proteins in neurodegeneration
CY Hsu, KT Lee, TY Sun, CI Sze, SS Huang, LJ Hsu… - Cells, 2021 - mdpi.com
WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for
Alzheimer's disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal …
Alzheimer's disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal …
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
Abstract Naked mole-rat (NMR), the longest-living rodent, produces very-high-molecular-
mass hyaluronan (vHMM-HA), compared to other mammalian species. However, it is …
mass hyaluronan (vHMM-HA), compared to other mammalian species. However, it is …
Principles of resonance energy transfer
Á Szabó, J Szöllősi, P Nagy - Current protocols, 2022 - Wiley Online Library
This unit describes the basic principles of Förster resonance energy transfer (FRET).
Beginning with a brief summary of the history of FRET applications, the theory of FRET is …
Beginning with a brief summary of the history of FRET applications, the theory of FRET is …
A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism
PY Chou, SR Lin, MH Lee, L Schultz, CI Sze… - Cell Communication and …, 2019 - Springer
Background Tumor suppressor WWOX physically binds p53 and TIAF1 and together
induces apoptosis and tumor suppression. To understand the molecular action, here we …
induces apoptosis and tumor suppression. To understand the molecular action, here we …
WWOX Controls Cell Survival, Immune Response and Disease Progression by pY33 to pS14 Transition to Alternate Signaling Partners
TY Liu, G Nagarajan, MF Chiang, SS Huang, TC Lin… - Cells, 2022 - mdpi.com
Tumor suppressor WWOX inhibits cancer growth and retards Alzheimer's disease (AD)
progression. Supporting evidence shows that the more strongly WWOX binds intracellular …
progression. Supporting evidence shows that the more strongly WWOX binds intracellular …
Normal cells repel WWOX-negative or-dysfunctional cancer cells via WWOX cell surface epitope 286-299
YA Chen, YD Sie, TY Liu, HL Kuo, PY Chou… - Communications …, 2021 - nature.com
Metastatic cancer cells are frequently deficient in WWOX protein or express dysfunctional
WWOX (designated WWOXd). Here, we determined that functional WWOX-expressing …
WWOX (designated WWOXd). Here, we determined that functional WWOX-expressing …
Therapeutic Zfra4-10 or WWOX7-21 peptide induces complex formation of WWOX with selective protein targets in organs that leads to cancer suppression and spleen …
WP Su, WJ Wang, JY Chang, PC Ho, TY Liu, KY Wen… - Cancers, 2020 - mdpi.com
Synthetic Zfra4-10 and WWOX7-21 peptides strongly suppress cancer growth in vivo.
Hypothetically, Zfra4-10 binds to the membrane Hyal-2 of spleen Z cells and activates the …
Hypothetically, Zfra4-10 binds to the membrane Hyal-2 of spleen Z cells and activates the …
Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal …
PY Chou, FJ Lai, YA Chen, YD Sie, HL Kuo… - Cell Death …, 2019 - nature.com
Proapoptotic tumor suppressor WWOX is upregulated in the early stage of cancer initiation,
which probably provides limitation to cancer growth and progression. Later, WWOX protein …
which probably provides limitation to cancer growth and progression. Later, WWOX protein …
WWOX Possesses N-Terminal Cell Surface-Exposed Epitopes WWOX7-21 and WWOX7-11 for Signaling Cancer Growth Suppression and Prevention In Vivo
WJ Wang, PC Ho, G Nagarajan, YA Chen, HL Kuo… - Cancers, 2019 - mdpi.com
Membrane hyaluronidase Hyal-2 supports cancer cell growth. Inhibition of Hyal-2 by specific
antibody against Hyal-2 or pY216-Hyal-2 leads to cancer growth suppression and …
antibody against Hyal-2 or pY216-Hyal-2 leads to cancer growth suppression and …
Three-fluorophore FRET enables the analysis of ternary protein association in living plant cells
N Glöckner, S zur Oven-Krockhaus, L Rohr… - Plants, 2022 - mdpi.com
Protein-protein interaction studies provide valuable insights into cellular signaling.
Brassinosteroid (BR) signaling is initiated by the hormone-binding receptor Brassinosteroid …
Brassinosteroid (BR) signaling is initiated by the hormone-binding receptor Brassinosteroid …