GHB is used therapeutically and recreationally, although the precise mechanism of action
responsible for its different behavioral effects is not entirely clear. The purpose of this review …

Abstract γ-Hydroxybutyric acid (GHB) is an endogenous compound in the mammalian brain
with both low-and high-affinity receptor targets. GHB is used clinically in the treatment of …

Ca2+/calmodulin-dependent protein kinase II alpha subunit (CaMKIIα) is a key neuronal
signaling protein and an emerging drug target. The central hub domain regulates the activity …

This chapter presents new clinical applications of the prototypic GABA B receptor agonist
baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine …

Misuse of gamma hydroxybutrate (GHB) and gamma butyrolactone (GBL) has increased
greatly since the early 1990s, being implicated in a rising number of deaths. This paper …

γ-Hydroxybutyric acid (GHB) binding to brain-specific high-affinity sites is well-established
and proposed to explain both physiological and pharmacological actions. However, the …

γ-Hydroxybutyric acid (GHB) is a naturally occurring γ-aminobutyric acid (GABA) metabolite
that has been proposed as a neurotransmitter/neuromodulator that acts via its own receptor …

γ‐Hydroxybutyrate (GHB) is a drug of abuse that causes euphoria, anxiolysis, and hypnosis.
The recent rise in the recreational intake of GHB, as well as its association with 'drug rape' …

The GABAB receptors are metabotropic G protein-coupled receptors (GPCRs) that mediate
the actions of the primary inhibitory neurotransmitter, γ-aminobutyric acid (GABA). In the …

In vitro autoradiography aims to visualize the anatomical distribution of a protein of interest
in tissue from experimental animals as well as humans. The method is based on the specific …