The role of retrotransposable elements in ageing and age-associated diseases
The genomes of virtually all organisms contain repetitive sequences that are generated by
the activity of transposable elements (transposons). Transposons are mobile genetic …
the activity of transposable elements (transposons). Transposons are mobile genetic …
Gut microbiome, big data and machine learning to promote precision medicine for cancer
The gut microbiome has been implicated in cancer in several ways, as specific microbial
signatures are known to promote cancer development and influence safety, tolerability and …
signatures are known to promote cancer development and influence safety, tolerability and …
Haplotype-resolved diverse human genomes and integrated analysis of structural variation
INTRODUCTION The characterization of the full spectrum of genetic variation is critical to
understanding human health and disease. Recent technological advances have made it …
understanding human health and disease. Recent technological advances have made it …
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues
L Zhang, A Richards, MI Barrasa… - Proceedings of the …, 2021 - National Acad Sciences
Prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
RNA and recurrence of PCR-positive tests have been widely reported in patients after …
RNA and recurrence of PCR-positive tests have been widely reported in patients after …
The genomic landscape of 2,023 colorectal cancers
Colorectal carcinoma (CRC) is a common cause of mortality, but a comprehensive
description of its genomic landscape is lacking,,,,,,–. Here we perform whole-genome …
description of its genomic landscape is lacking,,,,,,–. Here we perform whole-genome …
Extensive heterogeneity in somatic mutation and selection in the human bladder
The extent of somatic mutation and clonal selection in the human bladder remains unknown.
We sequenced 2097 bladder microbiopsies from 20 individuals using targeted (n= 1914 …
We sequenced 2097 bladder microbiopsies from 20 individuals using targeted (n= 1914 …
Pan-cancer analysis of whole genomes
Nature, 2020 - nature.com
Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …
BRCA mutations in ovarian and prostate cancer: bench to bedside
Simple Summary DNA damage is one of the hallmarks of cancer. Epithelial ovarian cancer
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …
[HTML][HTML] Patterns of somatic structural variation in human cancer genomes
A key mutational process in cancer is structural variation, in which rearrangements delete,
amplify or reorder genomic segments that range in size from kilobases to whole …
amplify or reorder genomic segments that range in size from kilobases to whole …
Measuring and interpreting transposable element expression
S Lanciano, G Cristofari - Nature Reviews Genetics, 2020 - nature.com
Transposable elements (TEs) are insertional mutagens that contribute greatly to the
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …