Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Mitigation of cardiovascular disease and toxicity through NRF2 signalling

JA Roberts, RD Rainbow, P Sharma - International journal of molecular …, 2023 - mdpi.com
Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact
on morbidity and mortality. The pathophysiology driving the development of these conditions …

[HTML][HTML] Serine/threonine kinase 3 promotes oxidative stress and mitochondrial damage in septic cardiomyopathy through inducing Kelch-like ECH-associated protein …

H Zhu, Z Dai, X Liu, H Zhou, Y Wang - International Journal of …, 2023 - ncbi.nlm.nih.gov
Abstract Serine/threonine kinases (STK3) is a core component of the Hippo pathway and
modulates oxidative stress and inflammatory responses in cardiovascular diseases …

Glucose increases hepatic mitochondrial antioxidant enzyme activities in insulin resistant rats following chronic angiotensin receptor blockade

JA Godoy-Lugo, MA Thorwald, DA Mendez… - International Journal of …, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) affects up to 20% of the world's population.
Overactivation of the angiotensin receptor type 1 (AT1) contributes to metabolic dysfunction …