The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates filamentation, biofilm formation, and …

VE Glazier, J Kramara, T Ollinger, NV Solis… - MBio, 2023 - Am Soc Microbiol
Candida albicans is a diploid human fungal pathogen that displays significant genomic and
phenotypic heterogeneity over a range of virulence traits and in the context of a variety of …

Reinforcement amid genetic diversity in the Candida albicans biofilm regulatory network

MV Cravener, E Do, G May, R Zarnowski… - PLoS …, 2023 - journals.plos.org
Biofilms of the fungal pathogen Candida albicans include abundant long filaments called
hyphae. These cells express hypha-associated genes, which specify diverse virulence …

Intravital imaging-based genetic screen reveals the transcriptional network governing Candida albicans filamentation during mammalian infection

RS Wakade, LC Ristow, M Wellington, DJ Krysan - Elife, 2023 - elifesciences.org
Candida albicans is one of the most common human fungal pathogens. C. albicans
pathogenesis is tightly linked to its ability to under a morphogenetic transition from typically …

Candida albicans natural diversity: a resource to dissect fungal commensalism and pathogenesis

E Lindemann-Perez, JC Perez - Current Opinion in Microbiology, 2024 - Elsevier
Candida albicans is a ubiquitous fungus of humans. It is not only a component of the oral
and intestinal microbiota of most healthy adults but also a major cause of mucosal disorders …

Candida albicans and Antifungal Peptides

CG Freitas, MS Felipe - Infectious Diseases and Therapy, 2023 - Springer
Candida albicans, a ubiquitous opportunistic fungal pathogen, plays a pivotal role in human
health and disease. As a commensal organism, it normally resides harmlessly within the …

Hgc1 independence of biofilm hyphae in Candida albicans

A Sharma, NV Solis, MY Huang, F Lanni, SG Filler… - Mbio, 2023 - Am Soc Microbiol
Biofilm and hypha formation are central to virulence of the fungal pathogen Candida
albicans. The G1 cyclin gene HGC1 is required for hypha formation under diverse in vitro …

Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection

QT Phan, NV Solis, MV Cravener, M Swidergall… - PLoS …, 2023 - journals.plos.org
Fungal invasion of the oral epithelium is central to the pathogenesis of oropharyngeal
candidiasis (OPC). Candida albicans invades the oral epithelium by receptor-induced …

Strain variation in gene expression impact of hyphal cyclin Hgc1 in Candida albicans

A Sharma, AP Mitchell - G3: Genes, Genomes, Genetics, 2023 - academic.oup.com
Formation of hyphae is a key virulence trait of the fungal pathogen Candida albicans. Hypha
morphogenesis depends upon the cyclin Hgc1, which acts together with cyclin-dependent …

Biofilm-associated metabolism via ERG251 in Candida albicans

L Xiong, N Pereira De Sa, R Zarnowski… - Plos …, 2024 - journals.plos.org
Biofilm formation by the fungal pathogen Candida albicans is the basis for its ability to infect
medical devices. The metabolic gene ERG251 has been identified as a target of biofilm …

The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain dependent

RS Wakade, M Wellington, DJ Krysan - Msphere, 2024 - Am Soc Microbiol
Candida albicans is one of the most common causes of superficial and invasive fungal
diseases in humans. Its ability to cause disease is closely linked to its ability to undergo a …