Drug discrimination research has generated rich evidence for the capacity of interoceptive
drug stimuli to control behavior by serving as discriminative cues. Owing to its …

Background Recent studies have suggested the role of mammalian target of rapamycin
complex 1 (mTORC1) in the pathophysiology of depression. Although venlafaxine was …

The use of both prescription and illicit drugs creates the potential for drug interactions as a
function of both pharmacokinetic and pharmacodynamic processes. One such interaction is …

Although cocaine-induced conditioned taste aversions (CTA) are well documented, little is
known about the basis for cocaine's aversive effects. To address the role of serotonin (5-HT) …

Although cocaine readily induces taste aversions, little is known about the mechanisms
underlying this effect. It has been suggested that its inhibitory effects at one of the …

Drug discrimination is a powerful tool for evaluating the stimulus effects of psychoactive
drugs and for linking these effects to pharmacological mechanisms. This chapter reviews the …

Supplemental Information: The mouse as a model for neuropsychiatric drug development James
R. Howe VI, Mark F. Bear, Peyman Gols Page 1 Supplemental Information: The mouse as a …

Drugs of abuse have both rewarding and aversive effects, and it is the balance of these
effects which impact abuse vulnerability. Although research has traditionally focused on the …