Promising therapeutic targets for treatment of rheumatoid arthritis

J Huang, X Fu, X Chen, Z Li, Y Huang… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …

The pathogenic role of angiogenesis in rheumatoid arthritis

HA Elshabrawy, Z Chen, MV Volin, S Ravella… - Angiogenesis, 2015 - Springer
Angiogenesis is the formation of new capillaries from pre-existing vasculature, which plays a
critical role in the pathogenesis of several inflammatory autoimmune diseases such as …

The role of CXCL16 in the pathogenesis of cancer and other diseases

J Korbecki, K Bajdak-Rusinek, P Kupnicka… - International journal of …, 2021 - mdpi.com
CXCL16 is a chemotactic cytokine belonging to the α-chemokine subfamily. It plays a
significant role in the progression of cancer, as well as the course of atherosclerosis, renal …

Chemokines and chemokine receptors as promising targets in rheumatoid arthritis

MA Murayama, J Shimizu, C Miyabe, K Yudo… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation
and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play …

Exosomes derived from endothelial progenitor cells attenuate vascular repair and accelerate reendothelialization by enhancing endothelial function

X Li, C Chen, L Wei, Q Li, X Niu, Y Xu, Y Wang, J Zhao - Cytotherapy, 2016 - Elsevier
Background aims Exosomes, a key component of cell paracrine secretion, can exert
protective effects in various disease models. However, application of exosomes in vascular …

Chemokine regulation of angiogenesis during wound healing

RJ Bodnar - Advances in wound care, 2015 - liebertpub.com
Significance: Angiogenesis plays a critical role in wound healing. A defect in the formation of
a neovasculature induces ulcer formation. One of the challenges faced by the clinician when …

Role of the CXCR6/CXCL16 axis in autoimmune diseases

N Bao, B Fu, X Zhong, S Jia, Z Ren, H Wang… - International …, 2023 - Elsevier
Abstract The C–X–C motif ligand 16, or CXCL16, is a chemokine that belongs to the ELR−
CXC subfamily. Its function is to bind to the chemokine receptor CXCR6, which is a G protein …

The role of CXC chemokines in cardiovascular diseases

X Lu, Z Wang, D Ye, Y Feng, M Liu, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular disease (CVD) is a class of diseases with high disability and mortality rates.
In the elderly population, the incidence of cardiovascular disease is increasing annually …

CXCL16 positively correlated with M2-macrophage infiltration, enhanced angiogenesis, and poor prognosis in thyroid cancer

MJ Kim, HJ Sun, YS Song, SK Yoo, YA Kim, JS Seo… - Scientific Reports, 2019 - nature.com
Although various chemokines have pro-tumorigenic actions in cancers, the effects of
CXCL16 remain controversial. The aim of this study was to investigate the molecular …

Chemokines in rheumatic diseases: pathogenic role and therapeutic implications

Y Miyabe, J Lian, C Miyabe, AD Luster - Nature Reviews Rheumatology, 2019 - nature.com
Chemokines, a family of small secreted chemotactic cytokines, and their G protein-coupled
seven transmembrane spanning receptors control the migratory patterns, positioning and …