Osteoarthritis (OA) is a degenerative disease that affects multiple cells and associated
extracellular matrix (ECM). Chondrocytes and chondroextracellular matrix together …

Cartilage defects are usually caused by acute trauma and chronic degeneration. However, it
is still a great challenge to improve the repair of articular cartilage defects due to the limited …

Abstract Atractylenolide‐III (AT‐III) is well known as its role in antioxidant and anti‐
inflammatory. Present study was aimed to figure out its effects on osteoarthritis and potential …

Background Intervertebral disc degeneration (IVDD) is a leading cause of low back pain
(LBP). The pathological process of IVDD is associated with inflammatory reactions and …

Osteoarthritis (OA) is the most common form of arthritis. However, the exact pathogenesis
remains unclear. Emerging evidence shows that N6-methyladenosine (m6A) modification …

Knee osteoarthritis (KOA) is a chronic, disabling knee joint lesion in which degeneration and
defects in articular cartilage are the most important features. Casticin (CAS) is a flavonoid …

Introduction Osteoarthritis (OA), the most common degenerative joint disease, can
eventually lead to disability. However, no safe or effective intervention is currently available …

Dysregulation of bone homeostasis is closely related to the pathogenesis of osteoporosis.
Suppressing bone resorption by osteoclasts to attenuate bone loss has been widely …

Background Osteoarthritis (OA), which is characterized by pain, inflammation and
pathological changes, is associated with abnormal lipid metabolism. Extensive studies have …

Objectives Accumulating evidence indicates a strong link between knee osteoarthritis (KOA)
and sarcopenia. However, the mechanisms involved have not yet been elucidated. This …