Introduction: About 20 patents have been published from 2013 to 2018 for developing
advanced cancer therapeutics by targeting tubulin polymerization. Currently, there are …

Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

Present study advocates the joint experimental and computational studies of two potent
benzoimidazole‐based hydrazones with chemical formula C23H18F2N4O (5a) and …

Cancer is the second life-threatening disease worldwide, and it resulted in around 9.6
million deaths globally in 2018. The multidrug-resistant cancers and non-selectivity create …

In the present study, fifteen benzimidazolyl-2-hydrazones 7a-7o of fluoro-, hydroxy-and
methoxy-substituted benzaldehydes and 1, 3-benzodioxole-5-carbaldehyde were …

The development of optically pure drugs is the trend of new drugs research. Searching for
optically pure metallodrugs against cancer has not been taken seriously.[CuL 4 Cl] Cl· 2CH …

Cancer is the second leading cause of death globally, with 9.6 million deaths yearly. As a life‐
threatening disease, it necessitates the emergence of new therapies. Resistance to current …

Dehydroabietic acid is a tricyclic diterpenoid resin acid isolated from rosin. Dehydroabietic
acid and its derivatives showed lots of medical and agricultural bioactivities, such as …

Inhibiting the tubulin-microtubules (Tub-Mts) system is a classic and rational approach for
treating different types of cancers. A large amount of data on inhibitors in the clinic supports …

Dehydroabietic Acid (DHA, 1) derivatives are known for their antiproliferative properties,
among others. In the context of this work, DHA was initially modified to two key intermediates …