Poor wound healing in individuals with diabetes has long plagued clinicians, and immune
cells play key roles in the inflammation, proliferation and remodeling that occur in wound …

The concept of a therapeutic cancer vaccine to activate anti-tumour immunity pre-dates
innovations in checkpoint blockade immunotherapies. However, vaccination strategies have …

In the tumor microenvironment (TME), CD8+ T cells showed stage exhaustion due to the
continuous stimulation of tumor antigens. To evaluate the status of CD8+ T cells and reverse …

Introduction Tumor-infiltrating lymphocytes are both prognostic and predictive biomarkers for
immunotherapy response. However, less is known about the survival benefits oftheir …

Hepatocellular carcinoma is one of leading causes of cancer-related mortality globally. The
emergence of immunotherapy has been shown to be a promising therapeutic approach for …

T cell immune dysfunction is a prominent characteristic of chronic lymphocytic leukemia
(CLL) and the main cause of failure for immunotherapy and multi-drug resistance. There …

Therapeutic cancer vaccines, whether based on neoantigens or shared antigens, will likely
be given in the clinic together with the standard of care, which often comprises immune …

The concept of a therapeutic cancer vaccine to activate anti-tumour immunity pre-dates
innovations in checkpoint blockade immunotherapies. However, vaccination strategies have …