With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Cells keep their energy balance and avoid oxidative stress by regulating mitochondrial
movement, distribution, and clearance. We report here that two Parkinson's disease …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by the degeneration of dopamine (DA) and non-DA neurons, the almost uniform presence of …

Parkinson's disease (PD) is the second most common neurodegenerative disorder that is
characterized by two major neuropathological hallmarks: the degeneration of dopaminergic …

The roles of the Wnt signalling pathway in several developmental processes, including
synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt …

Abstract Parkinson's disease (PD), like many common age-related conditions, has been
recognized to have a substantial genetic component. Multiple lines of evidence suggest that …

Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …

The leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of
autosomal-dominant Parkinson disease (PD). Mitochondrial dysfunction represents a critical …

Parkinson's disease (PD) is a complex disease, with genetics and environment contributing
to the disease onset. Recent studies of causative PD genes have confirmed the involvement …