Lipids rafts are considered to be functional nanoscale membrane domains enriched in
cholesterol and sphingolipids, characteristic in particular of the external leaflet of cell …

Over a third of women of childbearing age in the United States are obese, and during
pregnancy they are at increased risk for delayed labor onset and slow labor progress that …

Large-conductance Ca2+-activated K+ channels facilitate the efflux of K+ ions from a variety
of cells and tissues following channel activation. It is now recognized that BK channels …

Potassium (K+) ion channel activity is an important determinant of vascular tone by
regulating cell membrane potential (MP). Activation of K+ channels leads to membrane …

Ion transport across cell membranes is essential to cell communication and signaling.
Passive ion transport is mediated by ion channels, membrane proteins that create ion …

As described in the literature the interaction between cholesterol and membrane proteins
can occur via direct, ligand-like and indirect mechanisms, in which cholesterol effects are …

Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium-and voltage-gated potassium channels of large conductance …

Cholesterol decreases the activity of the majority of ion channels while increasing the activity
of only a few, yet it remains unclear how. Here, we used the inwardly rectifying potassium …

Cholesterol has been shown to promote cell proliferation/migration in many cells; however
the mechanism (s) have not yet been fully identified. Here we demonstrate that cholesterol …

Sterols associate preferentially with plasma membrane sphingolipids and saturated
phospholipids to form stoichiometric complexes. Cholesterol in molar excess of the capacity …