Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …

ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated
tumor suppressor genes in human cancers, especially in glioma, and recent findings …

Despite a conserved role for histones as general DNA packaging agents, it is now clear that
another key function of these proteins is to confer variations in chromatin structure to ensure …

Eukaryotic gene regulation involves a balance between packaging of the genome into
nucleosomes and enabling access to regulatory proteins and RNA polymerase …

Mutational inactivation of ATRX (α-thalassemia mental retardation X-linked) represents a
defining molecular alteration in large subsets of malignant glioma. Yet the pathogenic …

In eukaryotes, DNA is organized together with histones and non-histone proteins into a
highly complex nucleoprotein structure called chromatin, with the nucleosome as its …

The functional organization of eukaryotic DNA into chromatin uses histones as components
of its building block, the nucleosome. Histone chaperones, which are proteins that escort …