Absorption, distribution, metabolism and excretion (ADME) studies represent a fundamental
step in the early stages of drug discovery. In particular, the absorption of orally administered …

The main objective of this review is to discuss recent advancements in the overall
investigation and in vivo prediction of drug absorption. The intestinal permeability of an …

Background Large animal models, such as the dog, are increasingly being used for studying
diseases including gastrointestinal (GI) disorders. Dogs share similar environmental …

Identifying appropriate animal models is critical in developing translatable in vitro and in vivo
systems for therapeutic drug development and investigating disease pathophysiology …

The organoids represent one of the greatest revolutions in the biomedical field in the past
decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly …

Simple Summary Lipopolysaccharide (LPS) derived from intestinal bacteria is linked to long-
lasting inflammation that contributes to the development of intestinal cancer. While much …

Background The optimal medical treatment for chronic enteropathy (CE) in dogs and cats is
controversial. Sequential treatment using diet, antimicrobials, and immunosuppressive …

In recent years, the advent of intestinal organoid culture systems has revolutionized in vitro
studies of the small intestine epithelium. Intestinal organoids are derived from self …

In a recent issue of the Lancet, the prevalence of Inflammatory Bowel Disease (IBD) was
estimated at 7 million worldwide. Overall, the burden of IBD is rising globally, with direct and …

Recent advances in canine intestinal organoids have expanded the option for building a
better in vitro model to investigate translational science of intestinal physiology and …