ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute one of the
largest families of lipid-binding/transfer proteins (LTPs) in eukaryotes. The current view is …

The actin cytoskeleton is indispensable for several cellular processes, including migration,
morphogenesis, polarized growth, endocytosis, and phagocytosis. The organization and …

The endoplasmic reticulum (ER) forms direct membrane contact sites with the plasma
membrane (PM) in eukaryotic cells. These ER-PM contact sites play essential roles in lipid …

Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a
fundamental process underlying hypercholesterolemia, a high blood cholesterol …

Membrane contact sites between the cortical endoplasmic reticulum (ER) and the plasma
membrane (PM) provide a direct conduit for small molecule transfer and signaling between …

Fragments of the endoplasmic reticulum (ER) are selectively delivered to the lysosome
(mammals) or vacuole (yeast) in response to starvation or the accumulation of misfolded …

Lipids are amphiphilic molecules that self-assemble to form biological membranes.
Thousands of lipid species coexist in the cell and, once combined, define organelle identity …

Cellular condensation is a reinvigorated area of study in biology, with scientific discussions
focusing mainly on the forces that drive condensate formation, properties, and functions …

ER-plasma membrane (PM) contacts are proposed to be held together by distinct families of
tethering proteins, which in yeast include the VAP homologues Scs2/22, the extended …