Metabolic homeostasis in mammals is tightly regulated by the complementary actions of
insulin and glucagon. The secretion of these hormones from pancreatic β-cells and α-cells …

More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Recent clinical data have suggested a correlation between coronavirus disease 2019
(COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in …

The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes
develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …

Clinical and pathophysiological studies have shown type 2 diabetes to be a condition mainly
caused by excess, yet reversible, fat accumulation in the liver and pancreas. Within the liver …

Blood glucose levels are tightly controlled by the coordinated action of at least four cell types
constituting pancreatic islets. Changes in the proportion and/or function of these cells are …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Context: Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies
show that β-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage …