Many different types of cancer show a high incidence of TP53 mutations, leading to the
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have …

There is now strong evidence that mutation not only abrogates p53 tumor-suppressive
functions, but in some instances can also endow mutant proteins with novel activities. Such …

INTRODUCTION Cancer genome studies have contributed to the analysis and discovery of
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …

p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human
cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of …

Purpose: To analyze the impact of TP53 mutations on response to first-line tyrosine kinase
inhibitors (TKI) in patients with EGFR-mutated non–small cell lung cancer (NSCLC) …

Ample data indicate that mutant p53 proteins not only lose their tumour suppressive
functions, but also gain new abilities that promote tumorigenesis. Moreover, recent studies …

In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection
against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding …

The concept that dietary changes could improve the response to cancer therapy is extremely
attractive to many patients, who are highly motivated to take control of at least some aspect …

Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …

The tumor suppressor gene p53 has been implicated in the regulation of epithelial–
mesenchymal transition (EMT) and tumor metastasis by regulating microRNA (miRNA) …