Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …

Neuropathic pain is a leading cause of high-impact pain, is often disabling and is poorly
managed by current therapeutics. Here we focused on a unique group of neuropathic pain …

Although sex dimorphism is increasingly recognized as an important factor in pain, female-
specific pain signaling is not well studied. Here we report that administration of IL-23 …

Understanding the endogenous mechanisms regulating resolution of pain may identify
novel targets for treatment of chronic pain. Resolution of chemotherapy-induced peripheral …

The current paradigm is that inflammatory pain passively resolves following the cessation of
inflammation. Yet, in a substantial proportion of patients with inflammatory diseases …

Pain is an unpleasant but essential-to-life sensation, usually resulting from tissue damage.
When pain persists long after the injury has resolved, it becomes pathological. The precise …

Traumatic injuries of the central nervous system (CNS) affect millions of people worldwide,
and they can lead to severely damaging consequences such as permanent disability and …

The immune system and the peripheral sensory nervous system communicate through
hardwired and humoral routes using shared mediators and receptors. On the basis of …

Chronic pain is a maladaptive condition affecting 7%− 10% of the population worldwide and
can be accompanied by depression, anxiety, and insomnia. In particular, chronic pain is …