FDA-approved oligonucleotide therapies in 2017
CA Stein, D Castanotto - Molecular Therapy, 2017 - cell.com
Oligonucleotides (oligos) have been under clinical development for approximately the past
30 years, beginning with antisense oligonucleotides (ASOs) and apatmers and followed …
30 years, beginning with antisense oligonucleotides (ASOs) and apatmers and followed …
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
D Hanahan, J Folkman - cell, 1996 - cell.com
Introduction confirmed this result and further revealed that in the Blood vessels are
fundamentally composed of endotheabsence of access to an adequate vasculature, tumor …
fundamentally composed of endotheabsence of access to an adequate vasculature, tumor …
Angiogenesis
J Folkman - Biology of endothelial cells, 1984 - Springer
Angiogenesis Page 1 CHAPTER 42 Angiogenesis JUDAH FOLKMAN I. Introduction
Angiogenesis is the generation of new capillary blood vessels. While all subsequent vessels …
Angiogenesis is the generation of new capillary blood vessels. While all subsequent vessels …
Advances in healthcare electronics enabled by triboelectric nanogenerators
The treatment, diagnosis, and monitoring of diseases have attracted more and more
attention in recent years. Healthcare electronics help effectively treat and real‐time monitor …
attention in recent years. Healthcare electronics help effectively treat and real‐time monitor …
Structural basis for fibroblast growth factor receptor activation
FGF signaling plays a ubiquitous role in human biology as a regulator of embryonic
development, homeostasis and regenerative processes. In addition, aberrant FGF signaling …
development, homeostasis and regenerative processes. In addition, aberrant FGF signaling …
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF
S Higashiyama, JA Abraham, J Miller, JC Fiddes… - Science, 1991 - science.org
Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is
mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The …
mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The …
Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development
A Aigner, PE Ray, F Czubayko, A Wellstein - Histochemistry and cell …, 2002 - Springer
Fibroblast growth factors (FGFs) play important roles during fetal and embryonic
development. FGF-2 (basic FGF, bFGF) is widely expressed in the embryo and has been …
development. FGF-2 (basic FGF, bFGF) is widely expressed in the embryo and has been …
The FGF family of growth factors and oncogenes
C Basilico, D Moscatelli - Advances in cancer research, 1992 - Elsevier
Publisher Summary The family of fibroblast growth factors (FGF) is the largest family of
growth factors involved in soft–tissue growth and regeneration. The FGF family includes …
growth factors involved in soft–tissue growth and regeneration. The FGF family includes …
The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and …
JM Whitelock, AD Murdoch, RV Iozzo… - Journal of Biological …, 1996 - ASBMB
Perlecan is a modular heparan sulfate proteoglycan that is localized to cell surfaces and
within basement membranes. Its ability to interact with basic fibroblast growth factor (bFGF) …
within basement membranes. Its ability to interact with basic fibroblast growth factor (bFGF) …
[PDF][PDF] Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes …
I Giardino, D Edelstein… - The Journal of clinical …, 1994 - Am Soc Clin Investig
Intracellular sugars are more reactive glycosylating agents than glucose. In vitro
nonezymatic glycosylation of basic fibroblast growth factor (bFGF) by fructose, glucose-6 …
nonezymatic glycosylation of basic fibroblast growth factor (bFGF) by fructose, glucose-6 …