Context-specific regulation of extracellular vesicle biogenesis and cargo selection

AC Dixson, TR Dawson, D Di Vizio… - … Reviews Molecular Cell …, 2023 - nature.com
To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

Cellular and molecular mechanisms associating obesity to bone loss

YS Forte, M Renovato-Martins, C Barja-Fidalgo - Cells, 2023 - mdpi.com
Obesity is an alarming disease that favors the upset of other illnesses and enhances
mortality. It is spreading fast worldwide may affect more than 1 billion people by 2030. The …

[HTML][HTML] Adipocyte-derived extracellular vesicles promote breast cancer cell malignancy through HIF-1α activity

G La Camera, L Gelsomino, R Malivindi, I Barone… - Cancer letters, 2021 - Elsevier
Extracellular vesicles (EVs) are emerging key protagonists in intercellular communication
between adipocytes and breast cancer (BC) cells. Here, we described a new mechanism by …

[HTML][HTML] Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

A Al-Jipouri, À Eritja, M Bozic - International Journal of Molecular …, 2023 - mdpi.com
Extracellular vesicles (EVs) are nanoparticles released from various cell types that have
emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in …

The adipocyte–macrophage relationship in cancer: A potential target for antioxidant therapy

S Sanhueza, L Simón, M Cifuentes, AFG Quest - Antioxidants, 2023 - mdpi.com
Obesity has emerged as a major public health concern with a staggering 39% worldwide
prevalence as of 2021. Given the magnitude of the problem and considering its association …

Adipose tissue-derived extracellular vesicles and the tumor microenvironment: revisiting the hallmarks of cancer

JA Moraes, C Encarnação, VA Franco… - Cancers, 2021 - mdpi.com
Simple Summary Increased body fat is associated with an increased risk of 13 different
cancer types. Recent findings have demonstrated a close relationship between extracellular …

Adipocyte-derived extracellular vesicles promote prostate cancer cell aggressiveness by enabling multiple phenotypic and metabolic changes

F Fontana, M Anselmi, E Carollo, P Sartori, P Procacci… - Cells, 2022 - mdpi.com
Background: In recent decades, obesity has widely emerged as an important risk factor for
prostate cancer (PCa). Adipose tissue and PCa cells have been shown to orchestrate a …

Influence of extracellular vesicles on lung stromal cells during breast cancer metastasis

U Patel, D Susman, AL Allan - International Journal of Molecular Sciences, 2023 - mdpi.com
Breast cancer is a prominent cause of cancer diagnosis and death in women globally, with
over 90% of deaths being attributed to complications that arise from metastasis. One of the …

[HTML][HTML] The role of tissue-derived extracellular vesicles in tumor microenvironment

J Lin, W Lu, B Huang, W Yang, X Wang - Tissue and Cell, 2024 - Elsevier
The tumor microenvironment (TME) is a highly heterogeneous ecosystem that plays critical
roles in the initiation, progression, invasion, and metastasis of cancers. Extracellular vesicles …

Current landscape: the mechanism and therapeutic impact of obesity for breast cancer

C Zhao, W Hu, Y Xu, D Wang, Y Wang, W Lv… - Frontiers in …, 2021 - frontiersin.org
Obesity is defined as a chronic disease induced by an imbalance of energy homeostasis.
Obesity is a widespread health problem with increasing prevalence worldwide. Breast …