Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and
immunosuppressive therapeutics in the 1940s and their continued use and development …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Glucocorticoids (GCs) are steroids secreted by the adrenal cortex under the hypothalamic-
pituitary-adrenal axis control, one of the major neuro-endocrine systems of the organism …

Skeletal aging is characterized by low bone turnover and marrow fat accumulation.
However, the underlying mechanism for this imbalance is unclear. Here, we show that …

The skeleton is diverse in its functions, which include mechanical support, movement, blood
cell production, mineral storage and endocrine regulation. This multifaceted role is achieved …

Adipocytes occupy 70% of the cellular volume within the bone marrow (BM) wherein
multiple myeloma (MM) originates and resides. However, the nature of the interaction …

The adipose organ comprises two main fat depots termed white and brown adipose tissues.
Adipogenesis is a process leading to newly differentiated adipocytes starting from precursor …

The active ingredient of the traditional Chinese medicine comfrey is shikonin, a
naphthoquinone compound. The focus of this study was to investigate the effect of shikonin …

Adipose tissue exhibits a remarkable capacity to expand, contract, and remodel in response
to changes in physiological and environmental conditions. Here, we describe recent …

Abstract Space travel requires metabolic adaptations from multiple systems. While vital to
bone and blood production, human bone marrow adipose (BMA) tissue modulation in space …