Striatal dopamine (DA) release is critical for motivated actions and reinforcement learning,
and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here …

A loss of the excitation/inhibition (E/I) balance in the neural circuit has emerged as a
common neuropathological feature in many neurodevelopmental disorders. Rett syndrome …

Studies on MECP2 function and its implications in Rett Syndrome (RTT) have traditionally
centered on neurons. Here, using human embryonic stem cell (hESC) lines, we modeled …

Recent neuroscience studies have highlighted the critical role of glial cells in information
processing. This has increased the demand for technologies that selectively modulate glial …

Neuropsychiatric disorders such as schizophrenia or autism spectrum disorder represent a
leading and growing burden on worldwide mental health. Fundamental lack in …

Cognitive decline is a major symptom in Alzheimer's disease (AD), which is strongly
associated with synaptic excitatory-inhibitory imbalance. Here, we investigated whether …

Rett syndrome (RTT) is a rare neurodevelopmental disorder that is usually caused by
mutations of the MECP2 gene. Patients with RTT suffer from severe deficits in motor …

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that impacts a
variety of cognitive and behavioral domains. While a genetic component of ASD has been …

Autism Spectrum Disorder (ASD), Rett syndrome (RTT) and Angelman Syndrome (AS) are
neurodevelopmental disorders (NDDs) that share several clinical characteristics, including …

Overexpression of the Ube3a gene and the resulting increase in Ube3a protein are linked to
autism spectrum disorder (ASD). However, the cellular and molecular processes underlying …