Ageing is a process that gradually increases the organism's vulnerability to death. It affects
different biological pathways, and the underlying cellular mechanisms are complex. In view …

Extensive research has lead to a growing appreciation that the heart is acutely sensitive to a
broad array of toxicants via multiple routes of exposure. These agents are as diverse as the …

Despite the dramatic increase in human lifespan over the past century, there remains
pronounced variability in “health‐span,” or the period of time in which one is generally …

Stress is increasingly associated with heart dysfunction and is linked to higher mortality rates
in patients with cardiometabolic disease. Glucocorticoids are primary stress hormones that …

An inexorable decline in maximum heart rate (mHR) progressively limits human aerobic
capacity with advancing age. This decrease in mHR results from an age-dependent …

Mice are an ideal mammalian model for studying the genetics of aging: considerable
resources are available, the generation time is short, and the environment can be easily …

Objective Rapamycin, a powerful geroprotective drug, can have detrimental effects when
administered chronically. We determined whether intermittent treatment of mice can reduce …

Investigation of the molecular mechanisms of aging in the human heart is challenging
because of confounding factors, such as diet and medications, as well as limited access to …

Age-related remodeling of the heart causes structural and functional changes in the left
ventricle (LV) that are associated with a high index of morbidities and mortality worldwide …

Background A recent genome-wide association study identified a susceptibility locus for
atrial fibrillation at the KCNN3 gene. Since the KCNN3 gene encodes for a small …