Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior developing brain …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic
development and adult homeostasis. Wnt signaling is modulated by a number of …

The primary cilium has recently stepped into the spotlight, as a flood of data show that this
organelle has crucial roles in vertebrate development and human genetic diseases. Cilia …

Breaking the anterior–posterior symmetry in mammals occurs at gastrulation. Much of the
signalling network underlying this process has been elucidated in the mouse; however …

The Wnt signalling pathway is an ancient system that has been highly conserved during
evolution. It has a crucial role in the embryonic development of all animal species, in the …

The extracellular antagonists of the Wnt signalling pathway can be divided into two broad
classes. Both classes of molecule prevent ligand-receptor interactions, but by different …

Background Myeloma cells may secrete factors that affect the function of osteoblasts,
osteoclasts, or both. Methods We subjected purified plasma cells from the bone marrow of …