Potential therapeutic and ameliorative effects of ramipril alone and in combination with methylprednisolone for the cytokine releasing syndrome in mice: An in vivo …

MS Al-Naimi, AR Abu-Raghif - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Cytokine-releasing syndrome (CRS) is a special form of systemic inflammatory response
syndrome provoked by factors like viral infections and certain immunomodulatory drugs like …

Exposure to the environmental pollutant chlorpyrifos induces hepatic toxicity through activation of the JAK/STAT and MAPK pathways

H Fu, Y Ge, X Liu, S Deng, J Li, P Tan, Y Yang… - Science of The Total …, 2024 - Elsevier
Chlorpyrifos (CHP) is an inexpensive highly effective organophosphate insecticide used
worldwide. The unguided and excessive use of CHP by farmers has led to its significant …

Design of prodrug for stereoisomers of omapatrilat to cross the blood-brain barrier using docking, homology modeling, MD, and QM/MM methods

M Sargolzaei, H Nikoofard - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
In this study, we designed a suitable ester prodrug for omapatrilat to penetrate the blood-
brain barrier and treat CNS diseases. Based on the ADMET properties, the methyl …

Evaluation of antidiabetic and antioxidant effects of Polygonum cognatum Meisn. and phytochemical analysis of effective extracts

S Gözcü, RA Uğan, H Özbek… - Biomedical …, 2024 - Wiley Online Library
Abstract Polygonum cognatum Meisn.(Polygonaceae) is used both as food and as a folk
medicine to treat diabetes. This study aimed to evaluate the effect of the extracts, along with …

Bacteriocins Production Using Whey

A Ali, A Tahir, W Khalid, A Khan, XA Zeng… - Whey Valorization …, 2023 - Springer
The diverse class of antimicrobial proteins/peptides known as bacteriocins from lactic acid
bacteria (LAB) has the potential to be employed as bio-preservatives. They exhibit a variety …

[HTML][HTML] Protective Effects of ACE/NEP Dual Inhibitor Omapatrilat for Indomethacin-induced Gastric Ulcer

KG ERKAYMAN, U Rüstem Anıl, ZBA MAĞDEN… - 2023 - namikkemalmedj.com
Aim: The renin-angiotensin-aldosterone system (RAAS) plays important roles in oxidative
stress and various gastroenterological mechanisms. Omapatrilat, an RAAS-acting agent …

[HTML][HTML] ACE/NEP Dual İnhibitörü Omapatrilatın İndometazinle İndüklenen Mide Ülserinde Koruyucu Etkileri

KG ERKAYMAN, U Rüstem Anıl, ZBA MAĞDEN… - 2023 - namikkemalmedj.com
Amaç: Renin-anjiyotensin-aldosteron sistemi (RAAS), oksidatif stres ve çeşitli
gastroenterolojik mekanizmalarda önemli roller oynar. RAAS etkili bir ajan olan omapatrilat …