The research field of systems biology has greatly advanced and, as a result, the concept of
network pharmacology has been developed. This advancement, in turn, has shifted the …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

The PANTHER classification system (http://www. pantherdb. org) is a comprehensive system
that combines genomes, gene function classifications, pathways and statistical analysis …

Background Moluodan (MLD) is a traditional Chinese patent medicine for the treatment of
chronic atrophic gastritis (CAG). However, the mechanism of action (MoA) of MLD for …

Proteomics involves the applications of technologies for the identification and quantification
of overall proteins present content of a cell, tissue or an organism. It supplements the other …

Genomics, epigenomics, transcriptomics, proteomics and metabolomics efforts rapidly
generate a plethora of data on the activity and levels of biomolecules within mammalian …

Gene regulation plays a critical role in the cellular processes that underlie human health and
disease. The regulatory relationship between transcription factors (TFs), key regulators of …

The many functional partnerships and interactions that occur between proteins are at the
core of cellular processing and their systematic characterization helps to provide context in …

Just as reference genome sequences revolutionized human genetics, reference maps of
interactome networks will be critical to fully understand genotype-phenotype relationships …

The increasing number of experimentally detected interactions between proteins makes it
difficult for researchers to extract the interactions relevant for specific biological processes or …