Cognitive function relies on the dynamic cooperation of specialized regions of the brain;
however, the elements of the system responsible for coordinating this interaction remain …

The brain continuously adapts its processing machinery to behavioural demands. To
achieve this, it rapidly modulates the operating mode of cortical circuits, controlling the way …

Non-rapid eye movement (NREM) sleep, characterized by slow-wave electrophysiological
activity, underlies several critical functions, including learning and memory. However, NREM …

The basal ganglia (BG) are critical for adaptive motor control, but the circuit principles
underlying their pathway-specific modulation of target regions are not well understood …

During even the most quiescent behavioral periods, the cortex and thalamus express rich
spontaneous activity in the form of slow (< 1 Hz), synchronous network state transitions …

The pedunculopontine nucleus (PPN) has long been considered an interface between the
basal ganglia and motor systems, and its ability to regulate arousal states puts the PPN in a …

Cholinergic transmission in the striatal complex is critical for the modulation of the activity of
local microcircuits and dopamine release. Release of acetylcholine has been considered to …

Pedunculopontine nucleus region deep brain stimulation (DBS) is a promising but
experimental therapy for axial motor deficits in Parkinson's disease (PD), particularly gait …

The brain is a complex system that integrates and processes information across multiple
time scales by dynamically coordinating activities over brain regions and circuits …

Attention is a core cognitive function that filters and selects behaviourally relevant
information in the environment. The cortical mapping of attentional systems identified two …