This article profiles 13 newly approved nitrogen-containing heterocyclic drugs by the US
Food and Drug Administration (FDA) in 2023. These drugs target a variety of therapeutic …

Protein kinases have essential responsibilities in controlling several cellular processes, and
their abnormal regulation is strongly related to the development of cancer. The …

For the horseshoe tactic to succeed in inhibiting c-Met and Pim-1, the nicotinonitrile
derivatives (2a-n) were produced in high quantities by coupling acetyl phenylpyrazole (1) …

Abstract The phospatidylinositol-3 kinase (PI3K) pathway is a critical intracellular signalling
mechanism that is changed or amplified in a variety of cancers, including breast, gastric …

Cancer is one of the most significant health challenges worldwide. Various techniques, tools
and therapeutics/materials have been developed in the last few decades for the treatment of …

Chalcone derivatives were synthesized from 3, 4-dihydro-2H-naphthalen-1-one using a
base-catalyzed Claisen-Schmidt reaction and characterized by FT-IR, ¹H NMR, and ¹³C …

A new set of quinolin-4-ylcarbonylhydrazine derivatives 7a-i and 9a, b bearing 3-arylacryloyl
moiety has been synthesized and investigated for their potential anticancer activity. The …

Several new thiazole derivatives linked pyrazole and/or pyridine rings were synthesized
based on the versatile precursor 2-(5-acetyl-4-methyl-3-phenylthiazol-2 (3H)-ylidene) …

The prolonged or chronic use of anti-inflammatory agents that are being used clinically is
highly unsafe. This flaw or disadvantage has motivated scientists to create new heterocyclic …

Cancer is a complex disease driven by the dysregulation of multiple signaling pathways and
cellular processes. The development of compounds capable of exerting multitarget actions …