In situ solid-state nanopore fabrication

JP Fried, JL Swett, BP Nadappuram, JA Mol… - Chemical Society …, 2021 - pubs.rsc.org
Nanopores in solid-state membranes are promising for a wide range of applications
including DNA sequencing, ultra-dilute analyte detection, protein analysis, and polymer data …

Solid-state nanopores towards single-molecule DNA sequencing

Y Goto, R Akahori, I Yanagi, K Takeda - Journal of human genetics, 2020 - nature.com
Nanopore DNA sequencing offers a new paradigm owing to its extensive potential for long-
read, high-throughput detection of nucleotide modification and direct RNA sequencing …

Formation of single nanopores with diameters of 20–50 nm in silicon nitride membranes using laser-assisted controlled breakdown

C Ying, J Houghtaling, OM Eggenberger, A Guha… - ACS …, 2018 - ACS Publications
Nanopores with diameters from 20 to 50 nm in silicon nitride (SiN x) windows are useful for
single-molecule studies of globular macromolecules. While controlled breakdown (CBD) is …

In Situ Nanopore Fabrication and Single-Molecule Sensing with Microscale Liquid Contacts

CE Arcadia, CC Reyes, JK Rosenstein - Acs Nano, 2017 - ACS Publications
In this article, we introduce a flexible technique for high-throughput solid-state nanopore
analysis of single biomolecules. By confining the electrolyte to a micron-scale liquid …

Nanopores: a versatile tool to study protein dynamics

S Schmid, C Dekker - Essays in biochemistry, 2021 - portlandpress.com
Proteins are the active workhorses in our body. These biomolecules perform all vital cellular
functions from DNA replication and general biosynthesis to metabolic signaling and …

Precise fabrication of a 5 nm graphene nanopore with a helium ion microscope for biomolecule detection

Y Deng, Q Huang, Y Zhao, D Zhou, C Ying… - …, 2016 - iopscience.iop.org
We report a scalable method to fabricate high-quality graphene nanopores for biomolecule
detection using a helium ion microscope (HIM). HIM milling shows promising capabilities for …

Stable fabrication of a large nanopore by controlled dielectric breakdown in a high-pH solution for the detection of various-sized molecules

I Yanagi, R Akahori, K Takeda - Scientific reports, 2019 - nature.com
For nanopore sensing of various-sized molecules with high sensitivity, the size of the
nanopore should be adjusted according to the size of each target molecule. For solid-state …

Detection of single proteins with a general nanopore sensor

Q Li, YL Ying, SC Liu, Y Lin, YT Long - ACS sensors, 2019 - ACS Publications
Single protein sensing based on solid-state nanopores is promising but challenging,
because the fast translocation velocity of a protein is beyond the bandwidth of nanopore …

Photoactivated Bacteriorhodopsin/SiNx Nanopore-Based Biological Nanofluidic Generator with Single-Protein Sensitivity

D Wang, Y Wang, H Li, Y Han, P Hu, K Ma, M Sheves… - ACS …, 2022 - ACS Publications
Nanofluidics is an emerging hot field that explores the unusual behaviors of ions/molecules
transporting through nanoscale channels, which possesses a broad application prospect …

Real-time visualization and sub-diffraction limit localization of nanometer-scale pore formation by dielectric breakdown

A Zrehen, T Gilboa, A Meller - Nanoscale, 2017 - pubs.rsc.org
Herein, we introduce synchronous, real-time, electro-optical monitoring of nanopore
formation by DB. Using the same principle as sub-diffraction microscopy, our nanopore …