Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

The dynamic changes in chromatin conformation alter the organization and structure of the
genome and further regulate gene transcription. Basically, the chromatin structure is …

Developmental myelination is a protracted process in the mammalian brain. One theory for
why oligodendrocytes mature so slowly posits that myelination may stabilize neuronal …

Myelin is essential for rapid nerve signaling and is increasingly found to play important roles
in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as …

Previous work has shown that motor skill learning stimulates and requires generation of
myelinating oligodendrocytes (OLs) from their precursor cells (OLPs) in the brains of adult …

Abstract Oligodendrocytes (OLs), the myelin-forming cells of the central nervous system, are
integral to axonal integrity and function. Hypoxia-ischemia episodes can cause severe …

This article reviews the role of neuronal activity in myelin regeneration and the related
neural signaling pathways. The article points out that neuronal activity can stimulate the …

A central goal of neuroscience is to understand how the brain transforms external stimuli
and internal bodily signals into patterns of activity that underlie cognition, emotional states …

Myelin, which is produced by oligodendrocytes, insulates axons to facilitate rapid and
efficient action potential propagation in the central nervous system. Traditionally viewed as a …

Differential expression of myelin-related genes and changes in myelin thickness have been
demonstrated in mice after chronic psychosocial stress, a risk factor for anxiety disorders. To …