The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

Telomere attrition is associated with increased morbidity and mortality of various age-related
diseases. Reports of association between telomere length (TL) and all-cause mortality …

Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes.
Telomere attrition can lead to potentially maladaptive cellular changes, block cell division …

Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …

The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …

Background: Alzheimer's disease (AD) is a common and severe neurodegenerative
disorder. Human telomeres are fundamental for the maintenance of genomic stability and …

The global increases in life expectancy and population have resulted in a growing ageing
population and with it a growing number of people living with age-related …

Stress over the lifespan is thought to promote accelerated aging and early disease.
Telomere length is a marker of cell aging that appears to be one mediator of this …

Chronic kidney disease (CKD) is highly prevalent in the elderly population. However, it is
rarely investigated whether kidney function is causally linked to biological aging itself. In this …

The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …