Oxidative stress response pathways in fungi

H Yaakoub, S Mina, A Calenda, JP Bouchara… - Cellular and Molecular …, 2022 - Springer
Fungal response to any stress is intricate, specific, and multilayered, though it employs only
a few evolutionarily conserved regulators. This comes with the assumption that one …

Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction

S García-Santamarina, S Boronat, E Hidalgo - Biochemistry, 2014 - ACS Publications
Activation of redox cascades through hydrogen peroxide-mediated reversible cysteine
oxidation is a major mechanism for intracellular signaling. Understanding why some …

Epigenetic gene silencing by heterochromatin primes fungal resistance

S Torres-Garcia, I Yaseen, M Shukla, PNCB Audergon… - Nature, 2020 - nature.com
Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders
embedded genes transcriptionally silent,–. In the fission yeast Schizosaccharomyces …

Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast

A Rubio, S Ghosh, M Mülleder, M Ralser… - Nucleic Acids …, 2021 - academic.oup.com
Translational control is essential in response to stress. We investigated the translational
programmes launched by the fission yeast Schizosaccharomyces pombe upon five …

FgSKN7 and FgATF1 have overlapping functions in ascosporogenesis, pathogenesis and stress responses in Fusarium graminearum

C Jiang, S Zhang, Q Zhang, Y Tao… - Environmental …, 2015 - Wiley Online Library
Fusarium head blight caused by F usarium graminearum is one of the most destructive
diseases of wheat and barley. Deoxynivalenol (DON) produced by the pathogen is an …

ecl family genes: Factors linking starvation and lifespan extension in Schizosaccharomyces pombe

H Ohtsuka, Y Otsubo, T Shimasaki… - Molecular …, 2023 - Wiley Online Library
In the fission yeast Schizosaccharomyces pombe, the duration of survival in the stationary
phase, termed the chronological lifespan (CLS), is affected by various environmental factors …

[HTML][HTML] Yap1 homologs mediate more than the redox regulation of the antioxidant response in filamentous fungi

AE Mendoza-Martínez, N Cano-Domínguez, J Aguirre - Fungal biology, 2020 - Elsevier
The regulation of gene expression in response to increased levels of reactive oxygen
species (ROS) is a ubiquitous response in aerobic organisms. However, different organisms …

A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast

J Encinar del Dedo, N Gabrielli, M Carmona… - PLoS …, 2015 - journals.plos.org
Iron is an essential cofactor, but it is also toxic at high levels. In Schizosaccharomyces
pombe, the sensor glutaredoxin Grx4 guides the activity of the repressors Php4 and Fep1 to …

Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance

I Yaseen, SA White, S Torres-Garcia… - Nature structural & …, 2022 - nature.com
Epe1 histone demethylase restricts H3K9-methylation-dependent heterochromatin,
preventing it from spreading over, and silencing, gene-containing regions in fission yeast …

Dissection of a redox relay: H2O2-dependent activation of the transcription factor Pap1 through the peroxidatic Tpx1-thioredoxin cycle

IA Calvo, S Boronat, A Domenech… - Cell reports, 2013 - cell.com
In fission yeast, the transcription factor Pap1 undergoes H 2 O 2-dependent oxidation that
promotes its nuclear accumulation and the activation of an antioxidant gene program …