The intestinal epithelium can be easily disrupted during gut inflammation as seen in
inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn's disease. For a long …

The understanding of the intestinal inflammation occurring in the inflammatory bowel
diseases (IBD) has been immeasurably advanced by the development of the now numerous …

Background The intestine is inhabited by a tremendous number of microorganisms, which
provide many benefits to nutrition, metabolism and immunity. Mucosal barriers by intestinal …

Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between
sometimes hostile external environments and the internal milieu. However, mucosae are …

The primary functions of the gastrointestinal tract have traditionally been perceived to be
limited to the digestion and absorption of nutrients and to electrolytes and water …

Mammals and their intestinal microbiota peacefully coexist in a mutualistic relationship.
Commensal bacteria play an active role in shaping and modulating physiological processes …

The intestinal epithelium is a single-cell layer that constitutes the largest and most important
barrier against the external environment. It acts as a selectively permeable barrier …

Summary Interleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical
trials. Although inhibition of both of these cytokines is effective for treating psoriasis, IL-12 …

The gut mucosa is constantly challenged by a bombardment of foreign antigens and
environmental microorganisms. As such, the precise regulation of the intestinal barrier …

Epithelial and endothelial tight junctions act as a rate-limiting barrier between an organism
and its environment. Continuing studies have highlighted the regulation of the tight junction …