Introduction High-grade gliomas (HGG) are the most common malignant primary brain
tumors in adults, with a median survival of~ 18 months. The standard of care (SOC) is …

During the last 20 years, molecular alterations have gained increasing significance in the
diagnosis and biological assessment of tumors. Gliomas represent the largest group of …

Background Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant
brain tumor in children and can be subclassified into multiple entities. Fusion genes …

Aims Mitogen-activated protein kinase (MAPK) pathway alteration is a major oncogenic
driver in paediatric low-grade gliomas (LGG) and some adult gliomas, encompassing BRAF …

Background High-grade glioma (HGG) is a malignant brain tumor that is common and
aggressive in children and adults. In the current medical paradigm, surgery and …

Alterations of the fibroblast growth factor (FGF) signalling pathway are increasingly
recognized as frequent oncogenic drivers of paediatric brain tumours. We report on three …

Background Besides the hallmark of H3K27M mutation, aberrant amplifications of receptor
tyrosine kinases (RTKs) are commonly observed in diffuse midline glioma (DMG), a highly …

Canine high-grade oligodendrogliomas (HGOGs) exhibit a high expression of platelet-
derived growth factor receptor-α (PDGFRA). We examined PDGFRA mutations and gain of …

Despite improvements in patient outcomes, pediatric cancer remains a leading cause of non-
accidental death in children. Recent genetic analysis of patients with pediatric cancers …

Abstract Diffuse Midline Gliomas (DMGs) are universally fatal, primarily pediatric
malignancies affecting the midline structures of the central nervous system. Despite decades …