Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …

The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for
gene expression, and occurs principally at the initiation phase which is mainly regulated by …

Cancer stem cells (CSCs) virtually present in all tumors albeit in small numbers are primarily
responsible for driving cancer progression, metastasis, drug resistance, and recurrence …

Mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1/2) represent a central
class of enzymes that are activated by extracellular signal-regulated kinase (ERK) or p38 …

The MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate
eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the …

Abstract N7-methylguanosine (m7G) is one of the most common post-transcriptional
epigenetic modifications. Different m7G methyltransferases (writers) load the m7G-cap at the …

Prostate cancer (PCa) relies in part on AR-signaling for disease development and
progression. Earlier, we developed drug candidate galeterone, which advanced through …

Abstract The dysregulation of N (7)-methylguanosine (m7G) modification is increasingly
recognized as a key factor in the pathogenesis of cancers. Aberrant expression of these …

Overexpression of eIF4E is common in patients with various solid tumors and hematologic
cancers. As a potential anti-cancer target, eIF4E has attracted extensive attention from …

Background Lung cancer is the leading cause of mortality in cancer patients. N7-
methylguanosine (m7G) modification as a translational regulation pattern has been reported …