We are in the midst of a technological revolution that is providing new insights into human
biology and cancer. In this era of big data, we are amassing large amounts of information …

Recent decades have seen an alarming increase in the incidence of cardia gastric
adenocarcinoma (CGA) while noncardia gastric adenocarcinoma (NCGA) has decreased. In …

Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced
algorithms to identify drivers now exist, but systematic attempts to combine and optimize …

The anti-cancer immune response against mutated peptides of potential immunological
relevance (neoantigens) is primarily attributed to MHC-I-restricted cytotoxic CD8+ T cell …

Disparities in cancer care have been a long-standing challenge. We estimated the genetic
ancestry of The Cancer Genome Atlas patients, and performed a pan-cancer analysis on the …

Melanoma is a cancer of melanocytes, with multiple subtypes based on body site location.
Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal …

Cancers harbor many somatic mutations and germline variants, we hypothesized that the
combined effect of germline variants that alter the structure, expression, or function of protein …

Cancer development is a complex process driven by inherited and acquired molecular and
cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality …

Somatic evolution of cells within the body is well known to lead to cancers. However, spread
of somatic mutations within a tissue over time may also contribute to the pathogenesis of non …

Understanding the mechanisms underlying tumorigenesis requires comprehensive
annotation of the cancer genome. The majority of the human genome consists of noncoding …