Diagnostic uncertainties in tremor

L Marsili, M Bologna, A Mahajan - Seminars in Neurology, 2023 - thieme-connect.com
The approach and diagnosis of patients with tremor may be challenging for clinicians.
According to the most recent consensus statement by the Task Force on Tremor of the …

New horizons in late-onset essential tremor: a pre-cognitive biomarker of dementia?

X Wang, RJ St George, Q Bai, S Tran, J Alty - Age and Ageing, 2022 - academic.oup.com
Essential tremor (ET) is the most common cause of tremor in older adults. However, it is
increasingly recognised that 30–50% of ET cases are misdiagnosed. Late-onset ET, when …

[HTML][HTML] Age and sex affect Essential Tremor (ET) plus: clinical heterogeneity in ET based on the national survey in China

Q Sun, R He, H Huang, H Cao, X Wang, H Liu… - Aging and …, 2023 - ncbi.nlm.nih.gov
The new term essential tremor (ET) plus was proposed in the 2018 tremor consensus
criteria. The National Survey of Essential Tremor Plus in China, a large multicenter registry …

[HTML][HTML] The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis

OB Smeland, G Kutrolli, S Bahrami, V Fominykh… - medRxiv, 2023 - ncbi.nlm.nih.gov
While neurological and psychiatric disorders have historically been considered to reflect
distinct pathogenic entities, recent findings suggest shared pathobiological mechanisms …

Transcriptomic effects of propranolol and primidone converge on molecular pathways relevant to essential tremor

CE Castonguay, C Liao, A Khayachi, Y Liu… - NPJ Genomic …, 2022 - nature.com
Essential tremor (ET) is one of the most common movement disorders, affecting nearly 5% of
individuals over 65 years old. Despite this, few genetic risk loci for ET have been identified …

Gene expression analysis of laser-captured purkinje cells in the essential tremor cerebellum

RT Martuscello, K Sivaprakasam, W Hartstone, SH Kuo… - The Cerebellum, 2023 - Springer
Essential tremor (ET) is a common, progressive neurological disease characterized by an 8–
12-Hz kinetic tremor. Despite its high prevalence, the patho-mechanisms of tremor in ET are …

GWAS meta-analysis reveals key risk loci in essential tremor pathogenesis

AT Skuladottir, L Stefansdottir, GH Halldorsson… - Communications …, 2024 - nature.com
Essential tremor (ET) is a prevalent neurological disorder with a largely unknown underlying
biology. In this genome-wide association study meta-analysis, comprising 16,480 ET cases …

Genetics of Parkinson's disease heterogeneity: a genome-wide association study of clinical subtypes

J Dulski, RJ Uitti, A Beasley, D Hernandez… - Parkinsonism & Related …, 2024 - Elsevier
Introduction Substantial heterogeneity between individual patients in the clinical
presentation of Parkinson's disease (PD) has led to the classification of distinct PD subtypes …

Association of Gene Expression and Tremor Network Structure

T Welton, G Chew, AS Mai, JH Ng, LL Chan… - Movement …, 2024 - Wiley Online Library
Background Transcriptomic changes in the essential tremor (ET)–associated cerebello‐
thalamo‐cortical “tremor network” and their association to brain structure have not been …

[HTML][HTML] Association Between Common Variants in the LAG3/CD4 Genes and Risk for Essential Tremor

JAG Agúndez, Y Macías… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Many clinical, neuroimaging, neuropathological, epidemiological, and genetic data suggest
a relationship between essential tremor (ET) and Parkinson's disease (PD). Several …