At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

The Hemostatic System as a Modulator of Atherosclerosis | New England Journal of Medicine
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Discovered in the 1990s, protease activated receptors 1 (PARs) are membrane-spanning
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …

Background—Thrombin generation in vivo may be important in regulating atherosclerotic
progression. In the present study, we examined for the first time the activity and presence of …

Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is
associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and …

Background Variations in the blood coagulation activity, determined genetically or by
medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects …

The cytoprotective effects of activated protein C (aPC) are well established. In contrast, the
receptors and signaling mechanism through which aPC conveys cytoprotection in various …

Plaque rupture and subsequent thrombotic occlusion of the coronary artery account for as
many as three quarters of myocardial infarctions. The concept of plaque stabilisation …

The biochemical characterisation of the proteolytic pathways that constitute blood
coagulation was one of the most relevant achievements in biomedical research during the …

Although the link between blood coagulation and atherogenesis has been long postulated,
only recently, and through the extensive work on transgenic mice, crossbred on an …