Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

EA Donadi, EC Castelli, A Arnaiz-Villena… - Cellular and molecular …, 2011 - Springer
The HLA-G gene displays several peculiarities that are distinct from those of classical HLA
class I genes. The unique structure of the HLA-G molecule permits a restricted peptide …

Transcriptional and Posttranscriptional Regulations of the HLA-G Gene

EC Castelli, LC Veiga-Castelli, L Yaghi… - Journal of …, 2014 - Wiley Online Library
HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-
G coding region has been maintained during the evolution process, in which most of its …

Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity

EC Castelli, J Ramalho, IOP Porto, THA Lima… - Frontiers in …, 2014 - frontiersin.org
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I
genes, located within the major histocompatibility complex (MHC). HLA-G has been the …

Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention?

L Amiot, S Ferrone, H Grosse-Wilde… - Cellular and Molecular Life …, 2011 - Springer
Although the expression of the non-classical HLA class I molecule HLA-G was first reported
to be restricted to the fetal–maternal interface on the extravillous cytotrophoblasts, the …

HLA-G molecules in autoimmune diseases and infections

R Rizzo, D Bortolotti, S Bolzani, E Fainardi - Frontiers in immunology, 2014 - frontiersin.org
Human leukocyte antigen (HLA)-G molecule, a non-classical HLA-Ib molecule, is less
polymorphic when compared to classical HLA class I molecules. Human leukocyte antigen …

Genetic association between HLA-G 14-bp polymorphism and diseases: A systematic review and meta-analysis

BS de Almeida, YCN Muniz, AH Prompt, EC Castelli… - Human immunology, 2018 - Elsevier
Background HLA-G is an immune checkpoint molecule. Since a differential molecule
expression has been reported even for healthy individuals, many studies have focused on …

The role of HLA-G in human papillomavirus infections and cervical carcinogenesis

HH Xu, WH Yan, A Lin - Frontiers in immunology, 2020 - frontiersin.org
Human leukocyte antigen (HLA)-G, a non-classical HLA-class I molecule, has a low
polymorphism frequency, restricted tissue distribution and immunoinhibitory property. HLA-G …

Human leukocyte antigen (HLA)-E and HLA-G polymorphisms in human papillomavirus infection susceptibility and persistence

R Ferguson, AV Ramanakumar, H Richardson… - Human immunology, 2011 - Elsevier
Human leukocyte antigen (HLA)-E and HLA-G molecules act as powerful modulators of
innate and adaptive immune responses. The study examined whether HLA-E and/or HLA-G …

From HPV infection to lesion progression: the role of HLA alleles and host immunity

A Paaso, A Jaakola, S Syrjänen, K Louvanto - Acta cytologica, 2019 - karger.com
Persistent high-risk human papillomavirus (HPV) infection has been associated with
increased risk for cervical precancerous lesions and cancer. The host's genetic variability is …

Human leukocyte antigen G polymorphism is associated with an increased risk of invasive cancer of the uterine cervix

R Ferguson, AV Ramanakumar… - … Journal of Cancer, 2012 - Wiley Online Library
Human leukocyte antigen (HLA)‐G acts as negative regulator of the immune responses and
its expression in tumor cells may enable them to escape immunosurveillance. The purpose …