Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …

The innate immune response is a rapid response to pathogens or danger signals. It is
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …

In this era, it is axiomatic that cytokines have critical roles in cellular development and
differentiation, immune homeostasis, and host defense. Equally, dysregulation of cytokines …

Innate lymphoid cells (ILCs) and natural killer (NK) cells have garnered considerable
interest due to their unique functional properties in immune defense and tissue homeostasis …

How innate T cells (ITC), including invariant natural killer T (iNKT) cells, mucosal-associated
invariant T (MAIT) cells, and γδ T cells, maintain a poised effector state has been unclear …

A significant proportion of mammalian genomes corresponds to genes that transcribe long
non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning …

The immune system is composed of diverse cell types that coordinate responses to infection
and maintain tissue homeostasis. In each of these cells, extracellular cues determine highly …

Thousands of long noncoding RNAs (lncRNAs) are actively transcribed in mammalian
genomes. This class of RNAs has important regulatory functions in a broad range of cellular …

HCC is one of the most common malignant tumors and has an extremely poor prognosis.
Accumulating studies have shown that noncoding RNA (ncRNA) plays an important role in …

Multipotent progenitor cells confirm their T cell–lineage identity in the CD4–CD8–double-
negative (DN) pro-T cell DN2 stages, when expression of the essential transcription factor …