Atherosclerosis: the road ahead

CK Glass, JL Witztum - Cell, 2001 - cell.com
Lipoproteins and Atherosclerosis Christopher K. Glass*†‡ and Joseph L. Witztum*
Specialized Center of Research on Molecular Serum cholesterol is carried by several …

Genetically engineered pigs as models for human disease

C Perleberg, A Kind… - Disease models & …, 2018 - journals.biologists.com
Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis

PJ Barter, HB Brewer Jr, MJ Chapman… - … , and vascular biology, 2003 - Am Heart Assoc
Cholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters from
antiatherogenic HDLs to proatherogenic apolipoprotein B (apoB)–containing lipoproteins …

HDL function and atherosclerosis: reactive dicarbonyls as promising targets of therapy

MRF Linton, PG Yancey, H Tao, SS Davies - Circulation research, 2023 - Am Heart Assoc
Epidemiologic studies detected an inverse relationship between HDL (high-density
lipoprotein) cholesterol (HDL-C) levels and atherosclerotic cardiovascular disease …

High density lipoproteins and arteriosclerosis: role of cholesterol efflux and reverse cholesterol transport

A Von Eckardstein, JR Nofer… - … , thrombosis, and vascular …, 2001 - Am Heart Assoc
High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart
disease, and HDL exerts various potentially antiatherogenic properties, including the …

Liver X receptor signaling pathways in cardiovascular disease

P Tontonoz, DJ Mangelsdorf - Molecular endocrinology, 2003 - academic.oup.com
The liver X receptors α and β (LXRα and LXRβ) are members of the nuclear receptor family
of proteins that are critical for the control of lipid homeostasis in vertebrates. The …

Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL

VI Zannis, A Chroni, M Krieger - Journal of molecular medicine, 2006 - Springer
The concentration, composition, shape, and size of plasma high-density lipoprotein (HDL)
are determined by numerous proteins that influence its biogenesis, remodeling, and …

Reverse cholesterol transport and cholesterol efflux in atherosclerosis

R Ohashi, H Mu, X Wang, Q Yao, C Chen - Qjm, 2005 - academic.oup.com
Reverse cholesterol transport (RCT) is a pathway by which accumulated cholesterol is
transported from the vessel wall to the liver for excretion, thus preventing atherosclerosis …

[HTML][HTML] L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP

HL Collins, D Drazul-Schrader, AC Sulpizio, PD Koster… - Atherosclerosis, 2016 - Elsevier
Objective Dietary l-carnitine can be metabolized by intestinal microbiota to trimethylamine,
which is absorbed by the gut and further oxidized to trimethylamine N-oxide (TMAO) in the …

Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis

S Soltani, M Boozari, AFG Cicero… - Phytotherapy …, 2021 - Wiley Online Library
High‐density lipoprotein cholesterol (HDL) is the major promoter of reverse cholesterol
transport and efflux of excess cellular cholesterol. The functions of HDL, such as cholesterol …