Neuroinflammation in Alzheimer's disease

IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease

C Depp, T Sun, AO Sasmita, L Spieth, SA Berghoff… - Nature, 2023 - nature.com
The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …

The retina as a window to the brain—from eye research to CNS disorders

A London, I Benhar, M Schwartz - Nature Reviews Neurology, 2013 - nature.com
Philosophers defined the eye as a window to the soul long before scientists addressed this
cliché to determine its scientific basis and clinical relevance. Anatomically and …

A review: inflammatory process in Alzheimer′ s disease, role of cytokines

JM Rubio-Perez… - The Scientific World …, 2012 - Wiley Online Library
Alzheimer′ s disease (AD) is the most common neurodegenerative disorder to date.
Neuropathological hallmarks are β‐amyloid (Aβ) plaques and neurofibrillary tangles, but the …

Lymphatic drainage system of the brain: a novel target for intervention of neurological diseases

BL Sun, L Wang, T Yang, J Sun, L Mao, M Yang… - Progress in …, 2018 - Elsevier
The belief that the vertebrate brain functions normally without classical lymphatic drainage
vessels has been held for many decades. On the contrary, new findings show that functional …

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS

ED Ponomarev, T Veremeyko, HL Weiner - Glia, 2013 - Wiley Online Library
MicroRNAs (miRNAs) are a class of small (∼ 22 nucleotides) noncoding RNAs involved in
the regulation of gene expression at the post‐translational level. It is estimated that 30–90 …

Alzheimer's retinopathy: seeing disease in the eyes

N Mirzaei, H Shi, M Oviatt, J Doustar… - Frontiers in …, 2020 - frontiersin.org
The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD)
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …

100 years and counting: prospects for defeating Alzheimer's disease

ED Roberson, L Mucke - science, 2006 - science.org
This week marks a century since the first description of Alzheimer's disease (AD). Despite
approval of several drugs for AD, the disease continues to rob millions of their memories and …

Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms

M Sastre, T Klockgether, MT Heneka - International Journal of …, 2006 - Elsevier
There is compelling evidence that Alzheimer's disease (AD) amyloid-β (Aβ) deposition is
associated with a local inflammatory response, which is initiated by the activation of …