Tissue-resident memory CD8+ T cells are an important first line of defense from infection in
peripheral non-lymphoid tissues, such as the mucosal tissues of the respiratory, digestive …

A large proportion of memory T cells disseminated throughout the body are non‐
recirculating cells whose maintenance and function is regulated by tissue‐specific …

Most tissues are populated by tissue-resident memory T cells (TRM cells), which are
adapted to their niche and appear to be indispensable for local protection against …

Peripheral immune cell infiltration into the brain is a prominent feature in aging and various
neurodegenerative diseases such as Alzheimer's disease (AD). As AD progresses, CD8+ T …

CD8+ tissue-resident memory T (T RM) cells play crucial roles in defense against infections
and cancer and have been implicated in autoimmune diseases such as psoriasis. In mice …

Efficient immune responses against invading pathogens often involve coordination between
cells from both the innate and adaptive immune systems. For multiple decades, it has been …

The concept of immune privilege of the central nervous system (CNS) has dominated the
study of inflammatory processes in the brain. However, clinically relevant models have …

The central nervous system (CNS) is classically viewed as immune-privileged; however,
recent advances highlight interactions between the peripheral immune system and CNS in …

The skin is the largest organ of the body. The establishment of immunological memory in the
skin is a crucial component of the adaptive immune response. Once naive T cells are …

Toxoplasma gondii is a widespread parasitic pathogen that infects over a third of the world's
population. Following an acute infection, the parasite can persist within its mammalian host …