The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens
R Wyatt, J Sodroski - Science, 1998 - science.org
The human immunodeficiency virus–type 1 (HIV-1) envelope glycoproteins interact with
receptors on the target cell and mediate virus entry by fusing the viral and cell membranes …
receptors on the target cell and mediate virus entry by fusing the viral and cell membranes …
Pathogenesis of human immunodeficiency virus infection
JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …
number of different cells in the body and escaping the host immune response against it. HIV …
Dynamics of HIV infection of CD4+ T cells
We examine a model for the interaction of HIV with CD4+ T cells that considers four
populations: uninfected T cells, latently infected T cells, actively infected T cells, and free …
populations: uninfected T cells, latently infected T cells, actively infected T cells, and free …
A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1
Vaccination against human immunodeficiency virus type 1 (HIV-1) requires an immunogen
which will elicit a protective immunity against viruses that show a high degree of genetic …
which will elicit a protective immunity against viruses that show a high degree of genetic …
Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding
M Thali, JP Moore, C Furman, M Charles… - Journal of …, 1993 - Am Soc Microbiol
Interaction with the CD4 receptor enhances the exposure on the human immunodeficiency
type 1 gp120 exterior envelope glycoprotein of conserved, conformation-dependent …
type 1 gp120 exterior envelope glycoprotein of conserved, conformation-dependent …
Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants
SM Wolinsky, CM Wike, BTM Korber, C Hutto… - Science, 1992 - science.org
Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of
the envelope gene were analyzed from three mother-infant pairs. The infants' viral …
the envelope gene were analyzed from three mother-infant pairs. The infants' viral …
Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes
P Klenerman, RM Zinkernagel - Nature, 1998 - nature.com
Some viruses, including human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in
humans, and lymphocytic choriomeningitis virus (LCMV) in mice, are initially controlled by …
humans, and lymphocytic choriomeningitis virus (LCMV) in mice, are initially controlled by …
V3: HIV's switch-hitter
The third variable region, V3, of the gp120 surface envelope glycoprotein is an
approximately 35-residue-long, frequently glycosylated, highly variable, disulfide-bonded …
approximately 35-residue-long, frequently glycosylated, highly variable, disulfide-bonded …
Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS
Previously we identified the highly conserved amino acids Glu-Leu-Asp-Lys-Trp-Ala
(ELDKWA) on the ecto-domain of gp41 as the epitope of a neutralizing monoclonal antibody …
(ELDKWA) on the ecto-domain of gp41 as the epitope of a neutralizing monoclonal antibody …
Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell-line and macrophage tropism of human immunodeficiency virus type 1.
T Shioda, JA Levy… - Proceedings of the …, 1992 - National Acad Sciences
Human immunodeficiency virus type 1 (HIV-1) strains display a high degree of heterogeneity
in their biological properties that correlate with in vivo pathogenesis of the virus. We …
in their biological properties that correlate with in vivo pathogenesis of the virus. We …