Modeling alternative translation initiation sites in plants reveals evolutionarily conserved cis-regulatory codes in eukaryotes

TY Wu, YR Li, KJ Chang, JC Fang, D Urano… - Genome …, 2024 - genome.cshlp.org
mRNA translation relies on identifying translation initiation sites (TISs) in mRNAs. Alternative
TISs are prevalent across plant transcriptomes, but the mechanisms for their recognition are …

KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons

M Yheskel, HAM Hatch, E Pedrosa… - Nucleic Acids …, 2024 - academic.oup.com
Genes encoding the KDM5 family of transcriptional regulators are disrupted in individuals
with intellectual disability (ID). To understand the link between KDM5 and ID, we …

A perspective on Drosophila genetics and its insight into human neurodegenerative disease

NM Bonini - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Drosophila has been long appreciated as a classic genetic system for its ability to define
gene function in vivo. Within the last several decades, the fly has also emerged as a …