Cell‐to‐cell contact‐mediated regulation of tumor behavior in the tumor microenvironment

A Sato, NIA Rahman, A Shimizu, H Ogita - Cancer science, 2021 - Wiley Online Library
Tumor growth and progression are complex processes mediated by mutual interactions
between cancer cells and their surrounding stroma that include diverse cell types and …

The CPNE family and their role in cancers

H Tang, P Pang, Z Qin, Z Zhao, Q Wu, S Song… - Frontiers in …, 2021 - frontiersin.org
Lung cancer is the leading cause of cancer-related deaths worldwide. Despite significant
advances in cancer research and treatment, the overall prognosis of lung cancer patients …

Circulating exosomal CPNE3 as a diagnostic and prognostic biomarker for colorectal cancer

B Sun, Y Li, Y Zhou, TK Ng, C Zhao… - Journal of cellular …, 2019 - Wiley Online Library
Exosomal proteins are emerging as relevant diagnostic and prognostic biomarkers for
cancer. This study was aimed at illustrating the clinical significance of exosomal Copine III …

Integrated analysis of gene expression, CpG island methylation, and gene copy number in breast cancer cells by deep sequencing

Z Sun, YW Asmann, KR Kalari, B Bot… - PloS one, 2011 - journals.plos.org
We used deep sequencing technology to profile the transcriptome, gene copy number, and
CpG island methylation status simultaneously in eight commonly used breast cell lines to …

MicroRNA‐451 down‐regulates neutrophil chemotaxis via p38 MAPK

K Murata, H Yoshitomi, M Furu… - Arthritis & …, 2014 - Wiley Online Library
Objective MicroRNAs (miRNAs) are endogenous small noncoding RNAs that regulate the
activity of target messenger RNAs (mRNAs) and cellular processes. MicroRNA‐451 (miR …

Calcium pumps and interacting BON1 protein modulate calcium signature, stomatal closure, and plant immunity

DL Yang, Z Shi, Y Bao, J Yan, Z Yang, H Yu… - Plant …, 2017 - academic.oup.com
Calcium signaling is essential for environmental responses including immune responses.
Here, we provide evidence that the evolutionarily conserved protein BONZAI1 (BON1) …

CPNE1 is a target of miR-335-5p and plays an important role in the pathogenesis of non-small cell lung cancer

H Tang, J Zhu, W Du, S Liu, Y Zeng, Z Ding… - Journal of Experimental …, 2018 - Springer
Background Despite advances in diagnosis and treatment, the survival of non-small cell
lung cancer (NSCLC) patients remains poor. There is therefore a strong need to identify …

Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1

MKB Ahmat Amin, A Shimizu, DP Zankov, A Sato… - Oncogene, 2018 - nature.com
Tumor metastasis is the most common cause of cancer death. Elucidation of the mechanism
of tumor metastasis is therefore important in the development of novel, effective anti-cancer …

BON1 interacts with the protein kinases BIR1 and BAK1 in modulation of temperature‐dependent plant growth and cell death in Arabidopsis

Z Wang, P Meng, X Zhang, D Ren, S Yang - The Plant Journal, 2011 - Wiley Online Library
The Arabidopsis copine gene BON1 encodes a calcium‐dependent phospholipid‐binding
protein involved in plant growth homeostasis and disease resistance. However, the …

Copine 3 “CPNE3” is a novel regulator for insulin secretion and glucose uptake in pancreatic β-cells

W El-Huneidi, S Anjum, AK Mohammed… - Scientific Reports, 2021 - nature.com
Abstract Copine 3 (CPNE3) is a calcium-dependent phospholipid-binding protein that has
been found to play an essential role in cancer progression and stages. However, its role in …