In the human embryo, the genetic program that orchestrates germ cell specification involves
the activation of epigenetic and transcriptional mechanisms that make the germline a unique …

Spermatogenesis, a key part of the spermiation process, is regulated by a combination of
key cells, such as primordial germ cells, spermatogonial stem cells, and somatic cells, such …

The long-standing knowledge that Sertoli cells determine fetal testosterone production
levels is not widespread, despite being first reported over a decade ago in studies of mice …

Background Stem cell niche maintains stem cell population identity and is essential for the
homeostasis of self-renewal and differentiation in Drosophila testes. However, the …

In recent years, growing evidence demonstrates that mammalian Nanos RNA-binding
proteins (Nanos1, Nanos2, and Nanos3), known for their indispensable roles in germline …

Background Testicular germ cell tumor (TGCT) is the most common type of tumor in young
men. Type II germ cell tumors including postpubertal‐type teratomas are derived from the …

Spontaneous testicular teratomas (STTs) are tumours comprising a diverse array of cell and
tissue types, which are derived from pluripotent stem-like cells called embryonal carcinoma …

Teratomas are a highly differentiated type of testicular germ cell tumors (TGCTs), the most
common type of solid cancer in young men. Prominent inflammatory infiltrates are a hallmark …

Testicular teratomas and teratocarcinomas are the most common testicular germ cell tumors
in early childhood and young men, and they are frequently found unilaterally in the left testis …

Background Mesenchymal stromal/stem cells (MSCs) are known for their involvement in
modulating the immune system of mammals. This potency could be enhanced by different …