A safe and effective rotavirus vaccine is urgently needed, particularly in developing
countries. Critical to vaccine development and implementation is a knowledge base …

Rotavirus is the most common cause of severe diarrhoea in children worldwide and
diarrhoeal deaths in children in developing countries. Accelerated development and …

Background The safety and efficacy of an attenuated G1P [8] human rotavirus (HRV) vaccine
were tested in a randomized, double-blind, phase 3 trial. Methods We studied 63,225 …

Studies published between 1986 and 1999 indicated that rotavirus causes≈ 22%(range
17%–28%) of childhood diarrhea hospitalizations. From 2000 to 2004, this proportion …

Background Rotavirus vaccine use in national immunisation programmes has led to
declines in hospital admissions for rotavirus gastroenteritis among children; however, the …

Background We aimed to assess the efficacy of the oral live attenuated human rotavirus
vaccine Rotarix (RIX4414) for prevention of rotavirus gastroenteritis in European infants …

Background: A substantial number of surveillance studies have documented rotavirus
prevalence among children admitted for dehydrating diarrhea. We sought to establish global …

More than one billion diarrhea episodes occur every year among children younger than 5
years of age in socioeconomically developing countries causing 2 to 2.5 million deaths …

Background Information on the part that poor food-hygiene practices play a role in the
development of diarrhea in low socioeconomic urban communities is lacking. This study was …

Worldwide, enteric infections rank third among all causes of disease burden, being
responsible for some 1.7–2.5 million deaths per year, mostly in young children and infants in …